Pharmacology of non sedating antihistamines

This distinction between generations must be taken with caution because a product considered as non sedative or not antimuscarinic can, in certain circumstances, large doses or particular susceptibility of the patient ,have these effects.The drugs of the first antihistamine generation are: promethazine, alimemazine, dexchlorpheniramine, brompheniramine, buclizine, carbinoxamine and doxylamine, are sedating and elicit a drowsiness which can be awkward. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.In the fasting state bilastine is quickly absorbed, but the absorption is slowed when it is taken with food or fruit juice.

pharmacology of non sedating antihistamines-54

Scopolamine, an anticholinergic, is used for the prevention of motion sickness and for acute treatment.Antihistamines work by blocking the action of histamine which the body produces as part of its natural defences.Histamine is released as a reaction to foreign substances (allergens), and starts a chain reaction that leads to the release of other chemicals that add to the allergic response. There are two different types of antihistamine; sedating antihistamines, which can enter the brain and cause drowsiness and non-sedating antihistamines which do not.Current international guidelines need to be revised in the light of the recent evidence.Research into aspects of pharmacokinetics and efficacy and adverse effect profiles of bilastine in children under 12 years of age is needed as are dose-response assessments and studies planned rigorously with the aim of assessing quality of life effects.

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